The effect of papaya fruit (Carica papaya L.) on triglyceride levels in hypercholesterolemic Sprague Dawley rats. Volatile phytochemical composition of rhizome of ginger after extraction by headspace solid-phase microextraction, petrol ether extraction and steam distillation extraction. Jakarta: Departemen Kesehatan Republik Indonesia 2014. J Oleo Sci 2007 56:261-7ĭepartemen Kesehatan RI, Farmakope Indonesia. Mild ingestion of used frying oil damages hepatic and renal cells in Wistar rats. Anti-fatty liver effects of oils from Zingiber officinale and Curcuma longa on ethanol-induced fatty liver in rats. Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale) in rats. Denpasar: Universitas Udayana 2014.Įlrokh ESM, Yassin NAZ, El-Shenawy SMA, et al. Alpha lipoic acid oral inhibits improvement in number of steatosis and ALT levels in waste oil induced of male Wistar rat. Modulating effect of ginger extract on rats with ulcerative colitis. Ginger protects the liver against the toxic effects of xenobiotic compounds: preclinical observations. Haniadka R, Saxena A, Shivashankara AR, et al. Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase expression by Zingiber officinale in the liver of high-fat diet-fed rats. Chemical composition and antioxidant properties of ginger root (Zingiber officinale). Role of antioxidants in non-alcoholic fatty liver disease (NAFLD).
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Pathogenesis, diagnosis and treatment of non-alcoholic fatty liver disease.
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Martin-Dominguez V, Gonzalez-Casas R, Mendoza-Jimenez-Ridruejo J, et al. The intake of high fat diet with different trans fatty acid levels differentially induces oxidative stress and non alcoholic fatty liver disease (NAFLD) in rats. Moluca Medica 2011 4:61- 9.ĭhibi M, Brahmi F, Mnari A, et al. Administration of used cooking oil to mice causes liver cell damage and decreases serum albumin. Agric Biol J N Am 2010 1:501-9.ĭewi R, Sutejo IR. Effect of non-fried and fried oils of varied fatty acid composition on rat organs. Bulg Chem Commun 2012 44:57–63.įarag RS, Abdul-Latef MS, Basuny AMM, et al. Oxidative changes in some vegetable oils during heating at frying temperature. Marinova EM, Seizova KA, Totseva IR, et al. Gambaran anatomi mikroskopik dan kadar malondialdehida pada hati mencit setelah pemberian minyak kelapa sawit bekas menggoreng. Nat Rev Gastroenterol Hepatol 2013 10:307–18. NAFLD in Asia-as common and important as in the West. 21-404.įarrell GC, Wong VW-S, Chitturi S. Geneva: Springer international Publishing Switzerland 2016.p.
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Alcoholic and non-alcoholic fatty liver disease. Global epidemiology and risk factors for nonalcoholic fatty liver disease. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepat Mon 2013 13:1–8.Ĭhalasani N, Younossi Z, Lavine JE, et al. Probiotics as a novel treatment for non-alcoholic fatty liver disease: a systematic review on the current evidences. For the future research it is intended to prolong the induction time and the administration of red ginger rhizome extract. The Kruskal-Wallis test showed that fatty degeneration (steatosis, lobular inflammation, hepatocyte ballooning and NASH) were significantly different among the four groups (p0.05).ĭeep frying oil increased fatty degeneration and NASH, and none of red ginger rhizome extract doses was able to inhibit fatty degeneration significantly. The data were analyzed with the Kruskal-Wallis and Mann-whitney test. The histopathology examination assessed fatty degeneration, and degree of fibrosis. The treatment groups (P1, P2, P3) were given DFO-3 and red ginger rhizome extract at doses of 100, 200, and 400 mg/kg BW orally for 30 days. Group K1 (control) was given DFO-3 (3 times heated DFO) at a dose of 10 ìl/g BW/day. The present study was conducted to evaluate the hepatoprotective effect of an ethanol extract of Zingiber officinale Roxb var rubrum (EEZO) in DFO-fed male Wistar rats.Ī study of experimental design was conducted involving 24 non-alcoholic steatohepatitis (NASH) male Wistar rats that were randomly divided into 4 groups. Ginger has hypolipidemic and antioxidant properties, and acts as an insulin sensitizer.
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Non-alcoholic steatohepatitis (NASH) is a chronic liver disease associated with increased free fatty acids, trans fatty acids and free radical compounds due to the consumption of deep frying oil (DFO).